Allergic Reaction poster

Allergies. IgE inflammatory response. The antegen presenting cell draws in allergens, breaks them down with enzymes, and packages small pieces together with MHC class II molecules on its surface. This activates T lymphocytes to produce cytokines which drive up inflammation and also cause B lymphocytes to produce immunoglobulin (IgE) antibodies. Once sensitised, B cells differentiate into plasma cells which produce IgE antibodies that bind to granulocytes and mast cells. Further contact with the specific allergen causes the IgE on the surface of reactive cells to release preformed mediators including cytokines, histamine, leukotrienes, enzymes and tumour necrosis factor. Labelled.